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Wednesday, May 22, 2013
Yahoo Buying Tumblr for $1.1 Billion | Hawaii Reporter
The deal, announced Monday, is a bold bet by Yahoo Chief Executive Marissa Mayer to revitalize the company by co-opting a Web property with strong visitor traffic, but little revenue.
Yahoo made clear it was sensitive to concerns that it might damage Tumblr by making it less irreverent or more corporate.
?Per the agreement and our promise not to screw it up, Tumblr will be independently operated as a separate business,? Yahoo said in a statement.
The acquisition, which will use up about a fifth of Yahoo's $5.4 billion in cash and marketable securities, is the largest by far since Mayer took the reins in July with the goal of reversing a long decline in Yahoo's business and Web traffic.
Analysts said Yahoo appeared to be overpaying for a business that might not contribute to revenue for years, but said that Yahoo had to do something to plug a hole in its social media efforts.
RBC Capital Markets analyst Mark Mahaney called it a ?long-shot/long-term investment? but one that fits into Mayer's turnaround strategy.
?[Yahoo's] fundamentals have been subpar for numerous years, in part because of the company's missing presence in Social and Mobile. Tumblr may help [Yahoo] develop that presence,? Mahaney said in a note.
Tumblr is one of the Web's most popular hubs of so-called user-generated content, drawing young people who use the platform to post pictures and text. Tumblr has more than 100 million blogs in its network, ranging from ?White Men Wearing Google Glass? to housing-focused ?The Worst Room.?
Though Yahoo remains one of the Web's most popular destinations, it has seen its revenue shrink in recent years as consumers and advertisers favor rivals such as Google and Facebook. The deal is expected to increase Yahoo's audience by 50 percent.
Rich premium
While Tumblr is certainly popular - it has tens of millions of monthly unique visitors - analysts questioned what kind of contribution it will make to Yahoo revenue, since advertising on the site is in its nascent stages.
Media reports have pegged Tumblr's 2012 revenue at $13 million. The privately held company, based in Manhattan, does not disclose its financial results.
Yahoo expects that Tumblr will help boost revenue by 2014, Ken Goldman, Yahoo's chief financial officer, said on a call with analysts. He did not provide specific numbers.
?Even if revenue was $100 million, it means Yahoo paid 10 times revenue,? said BGC Financial analyst Colin Gillis. ?Ten times is what you pay to date the belle of the ball. It's on the outer bands of M&A.?
Yahoo could quickly boost Tumblr's revenue by combining the website with its own sales force, said Pivotal Research Group analyst Brian Wieser. Loading Tumblr up with banner ads risks alienating its users, however, and probably wouldn't provide a significant lift to Yahoo's overall revenue, he said.
?It's not clear that this deal will be favorable from a return-on-capital perspective,? Wieser said. ?One billion [dollars] for one company is a big bet.?
Gillis and Wieser were contacted on Sunday after the deal was reported by the online publication All Things D.
Mayer, on the conference call, described the Tumblr deal as an exception and said Yahoo was not necessarily planning lots of similarly sized deals.
Yahoo is one of several companies that have coughed up considerable money for buzz-worthy start-ups that hold promise. Facebook bought the popular social media photo site Instagram for $1 billion last year. In 2006, Google paid $1.6 billion for YouTube.
Shares of Yahoo rose as much as 2 percent in early trading Monday, but later fell back. They were up 18 cents to $26.70 in late-morning dealings. Through Friday's close, the shares had risen 70 percent since Mayer became CEO.
Image issues
One question Yahoo may have to address is Tumblr's reputation as a home for pornographic blogs. At one point in 2009, about 80 percent of Tumblr's top sites had something to do with adult content. Today that number is closer to 5 percent, according to Quantcast data, but the image lingers.
Mayer said on the call that Yahoo's targeting tools would allow advertisers to zero in on specific demographics and content.
One area where Yahoo plans to ramp up advertising: Tumblr's dashboard, the main landing point, akin to a newsfeed.
Dealing with that and other issues may fall to David Karp, 26, who founded Tumblr in 2007 and will remain CEO.
Karp, a self-taught programmer who left high school in favor of home schooling, did not take part in Mayer's conference call. Media reports have suggested his take in the billion-dollar sale would top $200 million.
In a 2012 interview with The Guardian, Karp seemed to be less interested in money than in Tumblr's prominence.
?There are a lot of rich people in the world. There are very few people who have the privilege of getting to invent things that billions of people use,? he said.
Source: http://www.hawaiireporter.com/yahoo-buying-tumblr-for-1-1-billion/123
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Microsoft unveils its next-generation Xbox One game console ...
Microsoft unveiled its next-generation Xbox, the Xbox One, this morning at an even on its campus.
The company?s aim is to usher in the next-generation of entertainment, using games as the Trojan horse into broader control of the living room. More than eight years in the making, the new machine represents the company?s ambitions to become the most important gaming and entertainment company in the world.
?Ladies and gentlemen, the Xbox One,? said Don Mattrick, head of Microsoft?s game business.
The system turns on in an instant with your voice commands.
It will be interesting to see the reception for it. The world has changed since Microsoft last introduced its Xbox 360 game console in 2005. Apple?s iPhone ushered in a new era of smartphones and tablets that are contenders for the leisure time of consumers. Microsoft has acknowledged this changing landscape and is making the new Xbox more connected than ever.
Nicknamed the Xbox 720, the new machine?s most direct competition will be the Sony PlayStation 4, which is expected to debut in November, as well as the Nintendo Wii U, a less-powerful system that is struggling to gain a foothold in the market. New game consoles typically sell millions at the outset, but Nintendo sold only 3.45 million units in its first five months.
Source: GamesBeat
The Xbox One?s revamped Kinect sensor.
Microsoft sold an estimated 77 million Xbox 360 game consoles during the current generation of hardware. Sony sold about the same, while Nintendo has sold 99 million Wiis. But Microsoft has dominated the charts of consoles sold and game sales for the past couple of years, and companies like Electronic Arts are betting heavily that it will be a leader in the next generation alongside Sony?s PlayStation 4.
Those results are far better than anyone ever expected from Microsoft, which was fundamentally a software company entering the hardware business back in 2001. With the original Xbox, Microsoft moved too slowly. It sold about 25 million units, beating Nintendo?s underpowered GameCube. But it was trounced by Sony?s PlayStation 2, which sold more than 150 million units in its lifetime.
Microsoft essentially moved from zero percent market share in 2000 to 12 percent market share in 2006 in the hardware business. And as the market currently stands, Microsoft has about 30 percent of the hardware unit market, compared to 30 percent for Sony and 40 percent for Nintendo. But in dollars, Microsoft?s share is higher than that, as Wii game sales slowed down dramatically in the last couple of years. Now the company plans to complete its conquest of video games in the coming generation.
The machine has an?accelerated processing unit (APU) chip from Advanced Micro Devices. AMD, which also makes the?APU for the PS4, is making a semi-custom chip for Microsoft, using eight processing cores, or computing brains, based on?Jaguar?micro-architecture?designs. The chip will combine graphics and processing on the same sliver of silicon, and it represents a shift away from IBM?s three-core Power chips that were used in the ?previous Xbox 360 game console.
Microsoft and Sony will likely distinguish itself based on the number of cores they will have in each chip. Sony has eight Jaguar cores in its chip, and it also has a special kind of graphics memory that will speed the transfer of data within the chip. Durango has an eight-core 64-bit APU running at 1.6GHz, with 8GBs of DDR3 main memory and a large hard disk. Microsoft?s machine has similar capabilities on the semiconductor level, but its games may not run as fast as Sony?s in part because Microsoft is expected to dedicate some of its performance to running?Kinect 2.
Kinect 2?is expected to be a more accurate version of the Kinect motion-sensing system that Microsoft launched in 2010. That system enabled players to control their games with gestures, rather than controllers, using body movements. But it wasn?t particularly accurate, and you had to stand in a sweet spot about 10 feet away from the console. With more processing power dedicated to the motion-sensing tasks, Microsoft will be able to make Kinect 2 more accurate and cover a wider area. Kinect 2 is expected to ship as standard on the new box, with better accuracy, improved voice recognition, a better camera, and dedicated hardware processing. If the latter is true, it will make the box more expensive to make. But the tax on processing power may not be as great.
Source: http://venturebeat.com/2013/05/21/microsoft-unveils-its-next-generation-xbox-one-game-console/
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Honeymoon Prank Leaves Newlyweds With Bright Pink House (PHOTO)
After a relaxing honeymoon, a pair of English newlyweds returned home on Sunday and discovered a shocking surprise: their house had been painted pink!
The BBC tweeted this photo Tuesday of Steve and Hayley O'Rourke's home, which Steve's brother, Russell, painted in the style of Mr. Blobby, a pink polka-dotted character from the 1990's British TV show "Noel's House Party."
The BBC reported that Russell painted the house as revenge: while Russell was on his honeymoon six years ago, Steve, a builder, built a brick wall in the middle of Russell's driveway.
Pranking honeymooning newlyweds isn't as uncommon as you might think. One couple's friends filled their house with balloons while they were away in 2011!
If you're thinking of pranking your newlywed friends, check out these tips.
Click through the slideshow below to see HuffPost readers' worst wedding disasters.
Keep in touch! Check out HuffPost Weddings on Facebook, Twitter and Pinterest.
Earlier on HuffPost:
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Source: http://www.huffingtonpost.com/2013/05/21/honeymoon-prank_n_3315025.html
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Tuesday, May 21, 2013
Poll: Teens migrating to Twitter
A view of an iPhone in Washington Tuesday, May 21, 2013, showing the Twitter and Facebook apps among others. A new poll finds that teens are sharing more about themselves on social media. They?re also moving increasingly to Twitter to avoid their parents and the "oversharing" that they see on Facebook. (AP Photo/Evan Vucci)
A view of an iPhone in Washington Tuesday, May 21, 2013, showing the Twitter and Facebook apps among others. A new poll finds that teens are sharing more about themselves on social media. They?re also moving increasingly to Twitter to avoid their parents and the "oversharing" that they see on Facebook. (AP Photo/Evan Vucci)
WASHINGTON (AP) ? Twitter is booming as a social media destination for teenagers who complain about too many adults and too much drama on Facebook, according to a new study published Tuesday about online behavior. It said teens are sharing more personal information about themselves even as they try to protect their online reputations.
Teens told researchers there were too many adults on Facebook and too much sharing of teenage angst and inane details like what a friend ate for dinner.
"The key is that there are fewer adults, fewer parents and just simply less complexity," said Amanda Lenhart of the Pew Research Center, one of the study's authors. "They still have their Facebook profiles, but they spend less time on them and move to places like Twitter, Instagram and Tumblr."
In the poll, 94 percent of teens who are social media users have a profile on Facebook ? flat from the previous year. Twenty-six percent of teen social media users were on Twitter. That's more than double the figure in 2011 of 12 percent.
"Facebook just really seems to have more drama," said 16-year-old Jaime Esquivel, a junior at C.D. Hylton High School in Woodbridge, Va., in an interview.
Esquivel said he still checks his Facebook account daily but isn't using it as regularly as in the past. He sees teens complaining on Twitter, too, so Esquivel has been using the photo-sharing service Instagram more often, posting a couple of pictures each day and communicating with friends. Facebook purchased Instagram last year.
In what may be a concern to parents, more than 60 percent of the teens with Twitter accounts said their tweets were public, meaning anyone on Twitter ? friend, foe or stranger ? can see what they write and publish. About one-quarter of kids said their tweets were private and 12 percent said they did not know whether their tweets were public or private.
Teens are also sharing much more than in the past.
More than 90 percent of teen social media users said they have posted a picture of themselves ? up from 79 percent in 2006, the poll said. Seven in ten disclose the city or town where they live, up from about 60 percent over the same time period. And 20 percent disclose their cell phone number ? up sharply from a mere two percent in 2006.
Even so, Parry Aftab, an attorney and online child safety advocate, says kids seem to be exercising more caution about their posts.
"They are sharing. This is their life," Aftab said in an interview. "But they tend to be sharing personal stuff far better than they ever did before."
The poll suggested teens are also taking steps to protect their reputations and mask information they don't want others to see. For example, nearly 60 percent of teen social media users said they have deleted or edited something that they had published. Just over half the teens have deleted comments from others on their profile or account.
The researchers surveyed 802 parents and their 802 teens. The poll was conducted between July 26 and September 30, 2012, on landline and cell phones. The margin of error for the full sample is plus or minus 4.5 percentage points.
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Chinese premier: Peace requires India-China trust
NEW DELHI (AP) ? The leaders of India and China played down their recent border dispute and other tensions Monday, pledging to work together for regional stability and the economic growth of the world's two most populous nations.
The Asian giants have vied in recent years for regional influence and access to oil needed to feed their growing economies.
Li Keqiang's trip to India, his first visit abroad since becoming premier, was part of an outreach mission by the new Chinese leadership to large emerging economies aimed at counter-balancing Beijing's fraught ties with the United States.
In that vein, Li ? and Indian Prime Minister Manmohan Singh ? sought Monday to focus on the opportunities for cooperation between their two nations.
"Both the prime minister and I believe that there are far more shared interests between China and India than the differences we have," Chinese Premier Li Keqiang said at a joint press conference.
"Without the common development of China and India, Asia won't become strong and the world won't become a better place," he said.
The summit was far heavier on symbolism than substance. The two sides signed eight minor agreements. But both leaders insisted the symbolism was important.
"I shared with Premier Li my view that the rise of China and India is good for the world and that the world has enough space to accommodate the growth aspirations of both our peoples. To make this a reality, it is important to build understanding between our two peoples," Singh said.
"We agreed that both sides must work to strengthen greater trust and confidence, which, in turn, will permit much larger cooperation," he added.
But the two nations have deep disputes, including China's unwavering support of Indian rival Pakistan and the two nations' competition for energy sources in the South China Sea. Even their $61.5 billion in trade last year was a source of tension, because it was heavily skewed in favor of China.
Their most volatile dispute remains their border disagreement, which flared up last month, just weeks before Li's planned visit.
India said Chinese troops crossed the defacto border on April 15 and pitched camp in the Depsang Valley in the Ladakh region of eastern Kashmir. New Delhi responded with diplomatic protests and then moved its soldiers just 300 meters (yards) from the Chinese position.
The two sides negotiated a peaceful end to the standoff three weeks later by withdrawing troops to their original positions in the Ladakh area.
The leaders said they both agreed that preserving peace along the borders was crucial to maintaining growth and asked mediators from both countries to work toward a framework for reaching a settlement.
India says China is occupying 38,000 square kilometers (15,000 square miles) of its territory in the Aksai Chin plateau in the western Himalayas, while China claims around 90,000 square kilometers (35,000 square miles) in India's northeastern state of Arunachal Pradesh. The two sides have held 15 rounds of fruitless border talks over the past decade.
___
Follow Ravi Nessman on Twitter at twitter.com/ravinessman
Source: http://news.yahoo.com/chinese-premier-peace-requires-india-china-trust-063211085.html
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Link between childhood ADHD and obesity revealed in first long-term study
May 20, 2013 ? A new study conducted by researchers at the Child Study Center at NYU Langone Medical Center found men diagnosed as children with attention-deficit/hyperactivity disorder (ADHD) were twice as likely to be obese in a 33-year follow-up study compared to men who were not diagnosed with the condition.
The study appears in the May 20 online edition of Pediatrics.
"Few studies have focused on long-term outcomes for patients diagnosed with ADHD in childhood. In this study, we wanted to assess the health outcomes of children diagnosed with ADHD, focusing on obesity rates and Body Mass Index," said lead author Francisco Xavier Castellanos, MD, Brooke and Daniel Neidich Professor of Child and Adolescent Psychiatry, Child Study Center at NYU Langone. "Our results found that even when you control for other factors often associated with increased obesity rates such as socioeconomic status, men diagnosed with ADHD were at a significantly higher risk to suffer from high BMI and obesity as adults."
According to the Centers for Disease Control and Prevention, ADHD is one of the most common neurobehavioral disorders, often diagnosed in childhood and lasting into adulthood. People with ADHD typically have trouble paying attention, controlling impulsive behaviors and tend to be overly active. ADHD has an estimated worldwide prevalence of five percent, with men more likely to be diagnosed than women.
The prospective study included 207 white men diagnosed with ADHD at an average age of 8 and a comparison group of 178 men not diagnosed with childhood ADHD, who were matched for race, age, residence and social class. The average age at follow up was 41 years old. The study was designed to compare Body Mass Index (BMI) and obesity rates in grown men with and without childhood ADHD.
Results showed that, on average, men with childhood ADHD had significantly higher BMI (30.1 vs. 27.6) and obesity rates (41.1 percent vs. 21.6 percent) than men without childhood ADHD.
"The results of the study are concerning but not surprising to those who treat patients with ADHD. Lack of impulse control and poor planning skills are symptoms often associated with the condition and can lead to poor food choices and irregular eating habits," noted Dr. Castellanos. "This study emphasizes that children diagnosed with ADHD need to be monitored for long-term risk of obesity and taught healthy eating habits as they become teenagers and adults."
The research was supported by grants MH-18579 and T32 MH-067763 from the National Institute of Mental Health, grant DA-16979 from the National Institute on Drug Abuse and grant PIOF-253103 from the European Commission.
Co-authors of the study include Salvatore Mannuzza, PhD (retired); Samuele Cortese, MD, PhD, of the Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience and Verona University, Italy; Erika Proal, PhD, of the Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience and Neuroingenia, Mexico; Rachel G. Klein, PhD, and Maria A. Ramos Olazagasti, PhD, of the Child Study Center at NYU Langone Medical Center.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/F-Y48m4kXdo/130520113925.htm
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Monday, May 20, 2013
Two suspected militants killed in Yemen drone strike
SANAA (Reuters) - Two suspected al Qaeda militants were killed on Monday in a drone strike on their vehicle south of the capital Sanaa, tribal and government sources said.
The strike follows another on Saturday in which at least four militants were killed in Abyan governorate, in southern Yemen. A Yemeni official did not say who was behind the attack, but previous strikes have been carried out by the United States.
Monday's strike occurred at dawn in the Radda area in al-Bayda province, but the sources gave no further details and Washington does not usually comment on drone strikes.
The United States has stepped up attacks on Yemen-based al Qaeda in the Arabian Peninsula (AQAP), once described by a senior U.S. official as the group's most dangerous branch after a plot by it to attack international airliners was foiled.
Yemen is next to the world's top oil exporter Saudi Arabia and major crude shipment routes.
Yemeni officials have said that at least six suspected militants were killed in two drone strikes last month. Another six suspected al Qaeda members were killed in January.
Militants allied to AQAP exploited Arab Spring chaos in Yemen in early 2011 to seize control of some towns in the country's southern provinces, including Radda and Jaar, where Saturday's strike occurred.
Although they were pushed from the towns last year they continue to fight government forces.
(Reporting by Mohammed Ghobari; Writing by Sami Aboudi; Editing by Alison Williams)
Source: http://news.yahoo.com/two-suspected-militants-killed-yemen-drone-strike-103927421.html
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Actavis buying Warner Chilcott in $8.5B deal
NEW YORK (AP) ? Actavis is buying Warner Chilcott in an all-stock deal valued at about $8.5 billion that would create the third-biggest specialty pharmaceutical company in the U.S. market.
The announcement Monday comes after the companies said earlier this month that they were in talks about a possible pairing of one of the world's largest generic drugmakers, Actavis Inc., with an Irish company that has a portfolio of established, branded drugs.
The combined company will be incorporated in Ireland, and analysts say that country's lower tax rate is a key to making the deal work. Actavis said it expects about $400 million in after-tax savings and cost cuts from the combination, counting the lower tax rate.
Generic drugmakers like Parsippany, N.J.-based Actavis have benefited the past couple years from the expiration of patents protecting top-selling drugs like the cholesterol fighter Lipitor. But many companies are competing for that revenue source, and analysts expect it to start drying up over the next few years.
The Warner Chilcott PLC deal will give Actavis an earnings jolt starting next year, Susquehanna Financial Group analyst Andrew Finkelstein said in a research note. But he added that he expects revenue from Warner Chilcott's product portfolio to decline modestly.
Morningstar analyst Michael Waterhouse said Warner Chilcott's pipeline of products under development also is weak, and he thought both companies were a bit overvalued heading into the deal.
"I would say we're probably not as enthusiastic as the market has been (about the acquisition)," Waterhouse said.
Actavis was formed last fall through a $5.6 billion combination of generic drugmaker Watson Pharmaceuticals of New Jersey and Actavis of Switzerland. It sells inexpensive generic versions of Lipitor, attention deficit hyperactivity disorder drugs Adderall XR and Concerta, Lovenox for preventing or breaking up dangerous blood clots and many other products. Actavis also has a U.S. pharmaceutical distribution business called Anda.
Warner Chilcott's products include the ulcerative colitis treatment Asacol, which is its top-selling drug, and Delzicol, another ulcerative colitis medication approved in February. Its revenue has been hurt the past couple years in part because low-cost generic versions of its osteoporosis drug Actonel went on sale in Western Europe and Canada in 2010, and U.S. sales have slipped as well.
In the deal announced Monday, Warner Chilcott shareholders will receive 0.160 shares of the new company for each share they own. This equals $20.08 per share, which is a 34 percent premium to the stock's closing price on May 9, the day before the companies said they were talking about a deal.
Warner Chilcott shareholders would then own a 23 percent stake in the new company.
Actavis Inc. shareholders will receive one share of the new company for each share they own.
Actavis CEO Paul Bisaro said in a statement that the deal will provide support for the launch of new women's health products over the next several years, including Minastrin 24 Fe birth-control pills, a progestin-only contraceptive patch and metronidazole gel for treating vaginal infections. Bisaro said it also gives Actavis a broader portfolio of specialty products that have sales potential outside North America.
Both companies' boards unanimously approved the deal, which is expected to close by year's end. It still needs the approval of the majority of shareholders of both companies.
The new company will be called Actavis PLC, and its U.S.-traded shares are expected to trade under the "ACT" ticker symbol on the New York Stock Exchange.
Monday's announcement follows reports that Actavis had rebuffed takeover bids from generic drugmaker Mylan Inc. and Canada's Valeant Pharmaceuticals International Inc. and that Novartis AG was considering a bid, something the Swiss drugmaker later denied. Analysts say any companies interested in Actavis could still step in with a fresh offer before the Warner Chilcott deal is completed.
Shares of Actavis climbed 2.6 percent, or $3211, to $128.71 in midday trading, while the Standard & Poor's 500 index was flat. The stock price has spiked 20 percent since the companies said on May 10 that they were in talks about a combination.
U.S.-traded shares of Warner Chilcott climbed more than 3 percent, or 59 cents, to $19.80. That price has climbed 32 percent since closing at $15.01 on May 9.
__
AP Business Writers Tom Murphy in Indianapolis and Linda A. Johnson in Trenton, N.J., contributed to this story.
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Afrojack, Baauer, Steve Aoki Reign Over EDM At Hangout Fest
Porter Robinson, Wolfgang Gartner, Benny Benassi also turned up the volume this weekend.
By Elizabeth Lancaster
Afrojack at the 2013 Hangout Music Festival
Photo:
Source: http://www.mtv.com/news/articles/1707642/best-edm-moments-hangout-festival-2013.jhtml
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Watch James Cameron's Aliens Animated in Just 60 Seconds
Who has time to watch a whole movie anymore? It's summer! So in the spirit of phoning in everything once the temperature rises above 70-ish, here's Ridley Scott's Aliens in 60 seconds of adorable animation. Brought to you, of course, by the fine folks who did Star Wars Episode IV
Edit: Aliens was, obviously, made by James Cameron, not Ridley Scott, and I am, obviously, an idiot. Sorry for any confusion, about Mr. Cameron's work or about my idiocy.
Source: http://gizmodo.com/watch-james-camerons-aliens-animated-in-just-60-second-508528275
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Metro-North: Conn. train outage expected for days
A derailed Metro-North rail car is hoisted back on to the tracks in Bridgeport. Conn. on Sunday, May 19, 2013. Crews will spend days rebuilding 2,000 feet of track, overhead wires and signals following the collision between two trains Friday evening that injured 72 people, Metro-North President Howard Permut said Sunday. (AP Photo/The Connecticut Post,Brian A. Pounds ) MANDATORY CREDIT
A derailed Metro-North rail car is hoisted back on to the tracks in Bridgeport. Conn. on Sunday, May 19, 2013. Crews will spend days rebuilding 2,000 feet of track, overhead wires and signals following the collision between two trains Friday evening that injured 72 people, Metro-North President Howard Permut said Sunday. (AP Photo/The Connecticut Post,Brian A. Pounds ) MANDATORY CREDIT
Metro-North employees work at the site of Friday's train derailment in Bridgeport. Conn. on Sunday, May 19, 2013. Crews will spend days rebuilding 2,000 feet of track, overhead wires and signals following the collision between two trains Friday evening that injured 72 people, Metro-North President Howard Permut said Sunday. (AP Photo/The Connecticut Post,Brian A. Pounds ) MANDATORY CREDIT
Map locates Bridgeport, Conn
BRIDGEPORT, Conn. (AP) ? Tens of thousands of commuters are bracing for a difficult trip around southwest Connecticut and to New York City beginning Monday as workers repair the Metro-North commuter rail line crippled by a derailment and crash.
Crews will spend days rebuilding 2,000 feet of track, overhead wires and signals following the collision between two trains Friday evening that injured 72 people, Metro-North President Howard Permut said Sunday. Nine remained hospitalized.
"This amounts to the wholesale reconstruction of a two-track electrified railroad," he said.
Several days of around-the-clock work will be required, including inspections and testing of the newly rebuilt system, Permut said. The damaged rail cars were removed from the tracks on Sunday, the first step toward making the repairs.
Service disruptions on the New Haven line between South Norwalk and New Haven are expected to continue "well into the coming week," Permut said.
Each day, approximately 30,000 Metro-North customers use the stations where service has been shut down, according to the Metropolitan Transportation Authority, which operates Metro-North.
Amtrak service between New York and New Haven also was suspended, and there was no estimate on service restoration. Limited service was available between New Haven and Boston.
Jim Cameron, chairman of a commuter group, the Connecticut Rail Commuter Council, said he's asked officials in numerous towns to suspend parking rules to accommodate what could be tens of thousands of motorists driving to unaffected train stations. Twelve stations are on the route that's been shut down.
The state Department of Transportation was expected to provide details Sunday on bus service between stations on Monday. Cameron said he doubts many commuters will use three modes of transportation to get to work: driving their cars to catch a bus to get to a train station for the final leg.
Commuters will more likely rely on their cars, leading to massive traffic problems on highways that are already clogged on normal days, Cameron said. He suggested that local and regional officials post highway signs directing motorists to available parking so motorists "don't get off the highway and drive in circles looking for where to dump their cars."
About 700 people were on board the trains Friday evening when one heading east from New York City's Grand Central Terminal to New Haven derailed just outside Bridgeport. It was hit by a train heading west from New Haven.
Dan Solomon, a trauma surgeon who lives in Westport and was headed to work at Yale-New Haven Hospital in New Haven, was on the train that derailed. He said he treated several injured passengers, including a woman with severely broken ankles.
He said he was in a front car that was not as badly affected as cars in the rear of the train.
"I hardly lost my iced tea," Solomon said in an interview.
He said walls were torn off both trains and he quickly checked injured passengers to separate the most badly injured from others.
"When the EMS arrived, I was covered in everyone's blood," he said.
Investigators are looking at a broken section of rail to see if it is connected to the derailment and collision.
NTSB investigators arrived Saturday and are expected to be on site for seven to 10 days. They will look at the brakes and performance of the trains, the condition of the tracks, crew performance and train signal information, among other things.
The MTA operates the Metro-North Railroad, the second-largest commuter railroad in the nation. The Metro-North main lines ? the Hudson, Harlem, and New Haven ? run northward from New York City's Grand Central Terminal into suburban New York and Connecticut.
The last significant train collision involving Metro-North occurred in 1988 when a train engineer was killed in Mount Vernon, N.Y., when one train empty of passengers rear-ended another, railroad officials said.
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2013 Billboard Music Award Winners & Performances (VIDEOS)
2013 Billboard Music Award Winners & Performances (VIDEOS)
2013 Billboard Music Award Winners & Performances (VIDEOS) Stupid Celebrities Gossip Stupid Celebrities Gossip News
Source: http://stupidcelebrities.net/2013/05/2013-billboard-music-award-winners-performances-videos/
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Dr Sherrill Sellman: What Women Must Know About Breast Cancer
Posted May 20, 2013
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Ever since Angelina Jolie announced that she has just undergone a double mastectomy to prevent breast cancer, the world seems to be buzzing about the topic. TV and social media have gone to town with this story, and while I may not agree with the messages that have been attached to it, I think it?s awesome that her story has got everyone thinking, talking and opening up healthy discussions about what is a very sensitive subject.
I?m not a breast cancer expert, but I do have access to people who are. Which is why I asked to speak with my friend Dr Sherrill Sellman about the topic. Dr Sellman is the author of What Women Must Know To Protect Their Daughters From Breast Cancer and Hormone Heresy: What Women Must Know About Their Hormones. She?s done extensive research in the fields of epigenetics and the breast cancer genes ? BRCA 1 and BRCA 2.
And while I may not be an expert, I?ve spent enough time researching and living this topic (both for my cancer and my mum?s) to be able to say that I firmly believe we have more options than what we?re led to believe by the mainstream world.
The intention of this interview isn?t to judge whether Angelina (or anyone else in her situation) made the right choice or not. We?re all different. We all have different fears, different conditioning, and different ways of looking at and understanding the world. But, what I do want to do is counteract the messages that are being pumped out by mainstream media by offering alternative answers to some of the questions and fears this story has stirred up.
In this interview, you will learn:
+ If you have the breast cancer genes, do you have options other than a double mastectomy when it comes to preventing breast cancer?
+ Why BRCA 1 and BRCA 2 aren?t the death sentences we?re led to believe they are.
+ What we can do to lower our risk of developing cancer ? whether we have the genes or not.
+ Why mammograms are the worst step for someone who has a predisposition to breast cancer and should never be used for screening purposes.
+ What to do instead of having a mammogram.
+ So much more on this very loaded topic.
Click here to listen:
DO YOU HAVE A QUESTION FOR SHERRILL?
On Wednesday morning, Sherrill and I will be holding a live Q&A call so that you can get answers to any questions you may have on this subject.
The call will be held at 9am (Australian EST). Click here to sign up and receive further details.
Can?t make that time? Sign up anyway to send through your question and receive a recording of the call.
SEE SHERRILL IN PERSON
Click here for a full list of Dr Sherrill Sellman?s Australian tour dates.
What did you think of this interview? I?d love for you to join in the conversation in the comments below. Politely though, please.
?
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Puzzling! Swine flu virus detected in elephant seals off West Coast
Joachim Ploetz, Alfred Wegener Institute
A male elephant seal opens wide at sea. Scientists have found the H1N1 virus strain in northern elephant seals off the coast of California, the first such detection in marine mammals.
By Megan Gannon, LiveScience
The H1N1 virus strain that caused a 2009 swine flu outbreak in humans was detected in northern elephant seals off the coast of central California.
Scientists say this is the first time marine mammals have been found to carry the H1N1 flu strain, which originated in pigs. The seals seem to have picked up the virus while at sea, but it's unclear how this happened.
"We thought we might find influenza viruses, which have been found before in marine mammals, but we did not expect to find pandemic H1N1," Tracey Goldstein, an associate professor with the UC Davis One Health Institute and Wildlife Health Center, said in a statement. [10 Deadly Diseases That Hopped Across Species]
"H1N1?was circulating in humans in 2009," Goldstein added. "The seals on land in early 2010 tested negative before they went to sea, but when they returned from sea in spring 2010, they tested positive. So the question is, where did it come from?"
Contact with humans carrying the virus is unlikely when the elephant seals are at sea, because the creatures spend most of their time looking for food in a remote part of the northeast Pacific Ocean off the continental shelf.
Exposure could have occurred through feces dumped out of shipping vessels passing through this area. The researchers noted in their report in the journal?PLOS ONE?this week that H1N1 has been detected in stool samples of hospital patients. Another possible avenue of transmission might have been contact with aquatic birds, thought to be reservoirs for other flu viruses, the researchers say.
Goldstein and colleagues tested nasal swabs from more than 900 Pacific marine mammals from 10 different species from Alaska to California between 2009 and 2011. The elephant seals that were studied had been satellite-tagged and tracked so that researchers could tell where they had been before and after they were tested for disease.
H1N1?was detected in two northern elephant seals within days of their return to land after they went out to sea to forage for a few months. Antibodies to the virus were found in another 28 elephant seals. None of the seals had any signs of illness, which means marine mammals can be infected with zoonotic pathogens but be asymptomatic, the researchers said.
The report recommends that people working with and around marine mammals need to take proper biosafety precautions to prevent exposure to diseases that could be quite harmful in humans, even if they don't cause illness in seals.
The new research on marine mammals is part of an effort to understand emerging viruses in animals and people by the Centers of Excellence in Influenza Research and Surveillance program, funded by the National Institutes of Health.
"The study of influenza virus infections in unusual hosts, such as?elephant seals, is likely to provide us with clues to understand the ability of influenza virus to jump from one host to another and initiate pandemics," Adolfo Garcia-Sastre, a professor of microbiology, said in a statement. Garcia-Sastre directs of the Global Health and Emerging Pathogens Institute at the Icahn School of Medicine, which collaborated with the team from UC Davis on the study.
Follow Megan Gannon on?Twitter?and?Google+.?Follow us?@livescience,?Facebook?and?Google+. Original article on?LiveScience.com.
Copyright 2013?LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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Sunday, May 19, 2013
Afghan police chief shot dead outside home
KABUL, Afghanistan (AP) ? Motorcycle-riding gunmen assassinated a police chief in front of his house after he led an anti-Taliban campaign in western Afghanistan, an official said Saturday.
Police Chief Abdul Ghani was leaving his driveway in his car outside his home in Farah province when the two raced up and opened fire.
Provincial spokesman Abdul Rahman Zhawandai said that Ghani was rushed to hospital after the attack Friday night but died of his wounds.
Ghani had recently launched a crackdown against insurgents in his district of Khaki Safad that resulted in the killing and capture of several Taliban leaders, Zhawandai said.
"Because he was an active commander in this district, he was a target of the Taliban," he said.
In the same province Saturday morning, four Afghan army soldiers died in Bakwa district when their vehicle hit a roadside bomb, the Defense Ministry said in a statement.
Afghan security forces and government officials are targeted by the Taliban to weaken the government of President Hamid Karzai ahead of the withdrawal of most international troops by the end of 2014.
Source: http://news.yahoo.com/afghan-police-chief-shot-dead-outside-home-070503949.html
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Friday, May 17, 2013
Klinefelter named one of agriculture's most influential thinkers by ...
Writer: Blair Fannin, 979-845-2259, b-fannin@tamu.edu
Contact: Dr. Danny Klinefelter, 979-845-7171, danklinefelter@tamu.edu
COLLEGE STATION ? Dr. Danny Klinefelter, a Texas A&M AgriLife Extension Service economist, was recently named to two distinguished groups of influential agricultural leaders by Top Producer magazine editors.
Klinefelter, also a professor in the department of agricultural economics at Texas A&M University, was part of Top Producer?s ?Brave Thinkers: 30 Leaders Who Made a Difference? and its ?7 Economists, Bankers Who Challenged the Status Quo.?
?The 30 brave thinkers we have chosen have all left big footprints on production agriculture,? according to the editors. ?As a group, they represent the diversity of U.S. agriculture and hail from companies, universities and the world of politics.?
Dr. Danny Klinefelter, Texas A&M AgriLife Extension Service economist.
The magazine said that during Klinefelter?s ?tenure at Texas A&M, ?he has advised thousands of producers nationwide about the best farm management practices. An agricultural economist by trade, he has become a popular speaker.
?While these are notable accomplishments, Klinefelter is best known for the creation of The Executive Program for Agricultural Producers. More than 1,700 producers have completed the two-week program, representing 8 percent of the U.S. farm production. The program is unique in that it is not commodity focused; it focuses entirely on the business of farming.?
The magazine noted the program?s instructors are ?the best nationwide, some agriculture, some strictly business.?
Klinefelter is also an advocate of peer advisory groups, where groups of eight to 10 producers, often from different regions, gather to work on problem-solving and explore opportunities, the editors noted.
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Google launches new Google+ Hangouts with focus on conversations
The rumors were apparently true: Google's unified chat platform (widely nicknamed Babel) is launching as part of a Hangouts redesign. The new service focuses on conversations that carry over from device to device, including notifications and shared photos; contacts are still there, but they're pushed to the side. Live group video is new, too, while text chats make it clearer as to who has been reading and typing. Android, iOS and web users all get access to the updated Hangouts today.
Filed under: Cellphones, Internet, Mobile, Google
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/_w_Jt_AHAVg/
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Dell's profit dives as billionaire battle rages on
By Poornima Gupta and Edwin Chan
SAN FRANCISCO (Reuters) - Dell Inc, the subject of a takeover battle between activist investor Carl Icahn and the company's billionaire founder, reported a 79 percent slide in profit as personal computer sales continued to shrink.
The disappointing results lend weight to Michael Dell's effort. The man who started Dell from a college dorm room wants to take the world's No.3 PC maker private for $24.4 billion, arguing that its transformation into a provider of enterprise computing services, from mainly a computer maker in a shrinking market, is best done away from public scrutiny.
Reflecting that shift in focus, Dell said on Thursday that revenue from enterprise solutions, services and software jumped 12 percent to $5.5 billion, while overall revenue slipped 2 percent. Its "end-user computing division," linked to PC sales, slid 9 percent.
To augment its enterprise business and go head-to-head with more established players like International Business Machines Corp and Hewlett-Packard Co, Dell is investing heavily on research and sales to retain customers.
Icahn and major stakeholder Southeastern Asset Management, however, dismiss Michael Dell's go-private deal as too cheap for a company trying to become a major provider of enterprise computing. They are proposing new leadership and additional cash or stock for shareholders.
"Hardware margins were pretty abysmal, which should generally support (Michael) Dell's bid," said Morningstar analyst Carr Lanphier. "But Michael Dell's strategy is also to be aggressive in pricing, to win key contracts."
"It doesn't seal the case one way or the other."
A FUTURE
Icahn's and Michael Dell's battle over what direction to take the company underscores the uncertainty in the PC industry, which enjoyed more than a decade of roaring growth until the advent of smartphones and tablets ended that era.
Now, the company that had been upheld as a model of innovation as recently as the early 2000s is steadily ceding ground to lower-cost Asian rivals and mobile hardware makers like Apple Inc.
"We made progress in building our enterprise solutions capabilities in the first quarter," Chief Financial Officer Brian Gladden said. "We have taken actions to improve our competitive position in key areas of the business, especially in end-user computing, and it has affected profitability."
Margins on a GAAP basis slid to 19.5 percent from 21.3 percent a year earlier, as total operating expenses climbed 12 percent.
Net income fell to $130 million from $635 million a year earlier. Excluding certain items, income was down 51 percent to $372 million, or 21 cents a share, from $761 million, or 43 cents a share, a year earlier.
That lagged by far the 35 cents Wall Street had expected.
Revenue in its fiscal first quarter ended May 3 fell to $14.1 billion, higher than the average analyst estimate of $13.5 billion according to Thomson Reuters I/B/E/S.
The company said it could not provide a financial outlook because it was in the midst of Michael Dell's go-private deal.
Shares in Dell slid 3 cents to $13.40 in after-hours trade, after closing at $13.43 on Nasdaq.
(Reporting by Poornima Gupta; Editing by Richard Chang)
Source: http://news.yahoo.com/dells-profit-dives-billionaire-battle-rages-003550823.html
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Google unveils maps, photo, music features
SAN FRANCISCO (AP) ? Google's sixth annual conference for software developers opened Wednesday with a chance for the company to showcase its latest services. Announcements include new features for online games, maps and search, a new music-streaming service and enhancements to its Google Plus social network, including tools for sharing and enhancing photos.
The audience of about 6,000 people at "Google I/O" includes engineers and entrepreneurs who develop applications and other features that can make smartphones and tablets more appealing. Reporters from around the world also will be on hand, giving Google a chance to generate more hoopla about its latest innovations.
Android already has been activated on 900 million devices made by Samsung Electronics Co., HTC Corp. and other manufacturers. Android devices are the chief rivals to Apple's iPhones and iPads. Android has helped Google make more money because its search engine and other services, including maps, are usually built into the devices. That tie-in drives more visitors to Google and gives the Mountain View, Calif., company more opportunities to sell ads.
Google's conference was being held at the Moscone Center in San Francisco.
The keynote kicked off at about 9 a.m. PDT and was expected to last nearly three hours. The conference goes through Friday.
Here's a running account of the event, presented in reverse chronological order. All times are PDT. Presenters include CEO Larry Page; Vic Gundotra, Google's senior vice president for engineering; Sundar Pichai, the head of Google's senior vice president for apps and the Chrome operating system for laptops; Hugo Barra, vice president for product management at Android; Ellie Powers, a product manager at Google; Brian McClendon, a vice president who oversees Google Maps; and Daniel Graf, director of Google Maps.
___
11:55 a.m.
Page complains about "the negativity of stories" in the news media. He says, "negativity isn't how we make progress. It's not zero-sum." He describes as "dumb" the stories that focus on rivalries, such as one between Google and Apple.
He also mentions his vision of driverless cars that will save people time and notes that "we are just scratching the surface of what is possible." Page says Google cooperated with Hollywood for the upcoming movie "The Internship" in order to address "a marketing problem" with technology.
___
11:45 a.m.
Page appears on stage, a day after the CEO disclosed a problem with his vocal cords that makes it difficult for him to speak and breathe occasionally. Page has said he remains fit enough to keep running Google. Page doesn't always appear at Google conferences, and his appearance Wednesday could be meant to reassure people.
On stage, he talks about how his dad was interested in technology and once drove him across the country to attend a robotics conference. He says it's important to focus on technology and get more people involved.
He says, "Technology should do the hard work so people can get on doing the things that make them happiest in life."
His voice sounds raspy, but that is usual.
___
11:40 a.m.
Google is also making images from its Google Earth service available on the Web browser. Before, you had to install separate software to use Google Earth. Google also demonstrates the ability to see a view of earth from space and rotate it around.
___
11:30 a.m.
Google introduces new features for its mapping apps on Android devices and iPhones.
When you search for restaurants in a city or neighborhood, you'll get the names of the restaurants along with its ratings at the bottom of the screen. You can swipe through the results horizontally. The mapping app will also include Google Offers ? deals akin to those from Groupon Inc. and LivingSocial.
___
11:20 a.m.
McClendon says Google has been trying to make its mapping services more useful by combining data from authoritative sources and using contributions from users. He says Google recently added more details on North Korea, with more listings of streets and parks rather than just a river and the city's name.
Graf takes a jab at Apple in talking about the success Google's mapping app has had on iPhones. Apple replaced Google's mapping service with its own app last fall. It resulted in complaints about inaccuracies and missing features. Google returned with its own mapping app a few months later. At Wednesday's conference, Graf points out that its app is "let's not forget, accurate."
___
11:05 a.m.
Google is trying to integrate what it knows about users with its search function, so it can reply to questions like "What's my gate number?" or "my restaurant reservation."
Google already makes this available through its Google Now service on Android devices, iPhones and iPads. Now, it's available to anyone using its Chrome browser on traditional computers.
___
10:50 a.m.
Google unveils several tools for sharing photos on its Google Plus social network.
One feature will pick out the best shots from a wide assortment of photos. Just upload a bunch, and Google's machines will reject ones that are blurry or don't have people smiling. Another factor is Google's knowledge of who's important to you ? so family members or close friends are more likely to make the cut.
If the photos don't look quite right, Google is promising to enhance them, taking over a job that typically requires people to use special photo-editing software such as Adobe System Inc.'s Photoshop, Apple's iPhoto or Google's Picasa. Computer-controlled editing tools will automatically soften skin tones and sharpen colors, for instance.
Google is also expanding the storage limit for full-resolution photos. Instead of five gigabytes for free per account, you'll get 15 gigabytes. Gundotra says that when you have an important photo, you don't want to sacrifice its quality to save space.
___
10:40 a.m.
Google is introducing 41 new features to its Google Plus social network, which Google is positioning as an alternative to Facebook.
Among them is a newly designed stream of content ? one designed to be dynamic, rather than a long list seen in Facebook.
Google Plus will start to display automatic hash tags to identify the main topic being discussed in a post or featured in a photo. You'll have the option to turn it off or remove it for a specific post. Google will also help you discover content by pulling up other posts with that hash tag. Facebook doesn't currently use hash tags.
Google is also streamlining its communications tools, offering a new app to combine its chat and Hangout services. Gundotra notes that Google's own services can be fragmented and confusing at time. The new app is designed to address that and can keep a record of past conversations. It will be available for Android and Apple devices, as well as regular Web browsers on computers.
The changes will start appearing Wednesday afternoon.
___
10:25 a.m.
Google unveils a program to get Android tablets into schools. One feature will allow educators to distribute an app to hundreds of tablets with a single click. Schools will able to pay for apps by charging against an account set up ahead of time. Normally, a credit card is required.
Google says Google Play for Education will launch this fall.
___
10:20 a.m.
Everyone in the audience is getting a free Chromebook Pixel, a high-end laptop developed by Google. It has a high-resolution touch-screen display and usually carries a high price tag ? starting at $1,299. It runs Google's Chrome operating system, which is meant mostly for online use.
Google has said that selling Pixels isn't the company's main goal with the machine. Rather, the company made it to showcase Google's vision for the future of computing. So giving Pixels away to engineers and entrepreneurs is consistent with that strategy.
___
10:15 a.m.
Google demonstrates the ability to play games simultaneously on its Chrome browser. Everything stays in sync even though the devices used varied.
___
10:10 a.m.
Google's stock broke $900 for the first time shortly before the conference started. At 10:10 a.m. PDT (1:10 p.m. EDT), it was up $18.72, or 2.1 percent, at $905.84. Google's market value also surpassed $300 billion for the first time.
___
10 a.m.
There's a new phone from Google. It will run on a newer version of the Android operating system, version 4.2. The Android version will still be called Jelly Bean, rather than Key Lime Pie ? the next in a series of dessert-themed code names.
It will be unlocked, meaning it will work with any carrier, including those abroad. But it also means the price won't be subsidized by the carrier. Google will sell it for $649 starting June 26, rather than the usual $200 or so with a two-year contract.
Google says the new phone is a variant of Samsung's Galaxy S4 phone, which was recently released.
Google also says that the new phone will be able to get Android updates as we come. U.S. carriers sometimes block those updates from getting to locked phones.
___
9:50 a.m.
Google unveils a music service called All Access. The streaming service will allow Android users to listen to their favorite songs and artists for a monthly fee.
Google wants to not only offer access to millions of songs, but also help guide you to music you might like. You can choose one of 22 music genres and see key albums that define the genre along with recommendations from Google's curators. You can listen to any track right away, or switch to a "radio station" format featuring songs you'll likely want to hear. You can adjust the playlist as you go.
The cost is $9.99 a month in the U.S., after a 30-day free trial. It launches in the U.S. Wednesday. If you start the trial by June 30, the monthly fee will drop to $7.99. It will be available in other countries later.
Google's All Access will be competing with Spotify and other popular music services.
___
9:45 a.m.
Google says its online Play store will make recommendations for apps, books, movies and music based on the device you are using. After all, what works well on a tablet might not on a phone.
___
9:40 a.m.
Powers introduces a service to help software developers get more users and make more money through their apps.
It will tell a developer, for instance, that an app is particularly popular in Russia, so that the developer could consider making a Russian-language version. Google is offering an app-translation service to help with that.
Another feature is designed to help developers understand how effective their ads are in getting people to download their apps.
___
9:30 a.m.
Google unveils a tool to help software developers make sure their apps work well on different screen sizes. That's important because some people use phones and others use mid-size or larger tablets. Developers will want to make sure their apps are pleasant across the board.
___
9:25 a.m.
Google introduces a technology for syncing notifications on different devices. The idea is when you dismiss a notification about a new Facebook message, for instance, it wouldn't reappear when you check your tablet.
Google also unveils new gaming tools. You can save where you are in a game and pick up on another device. You can also see how you rank on new leaderboards. This appears similar to what Apple offers on iPhones and iPads through its Game Center. Getting into gaming gives Google an opportunity to participate in one of the most popular activities on mobile devices.
___
9:20 a.m.
Barra introduces a few tools for software developers to incorporate into their apps. One allows apps to track what users are doing, such as walking. It may appear creepy to users, but Barra says the tools will allow developers to create "a whole new category of awesome apps."
___
9:10 a.m.
Pichai talks about Google having two large, fast-growing platforms: Android for smartphones and tablets and Chrome for laptops.
He says Android has grown from being on 100 million devices in 2011, 400 million in 2012 to 900 million now. He calls the growth "extraordinary." He suggests there's still room for growth with 7 billion people in the world.
___
9 a.m.
After a brief multimedia presentation, Gundotra appears on stage to open the conference.
Source: http://news.yahoo.com/google-unveils-maps-photo-music-features-183743020.html
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Thursday, May 16, 2013
Brain-imaging study links cannabinoid receptors to post-traumatic stress disorder: First pharmaceutical treatment for PTSD within reach
May 14, 2013 ? In a first-of-its-kind effort to illuminate the biochemical impact of trauma, researchers at NYU Langone Medical Center have discovered a connection between the quantity of cannabinoid receptors in the human brain, known as CB1 receptors, and post-traumatic stress disorder, the chronic, disabling condition that can plague trauma victims with flashbacks, nightmares and emotional instability.
Their findings, which appear online today in the journal Molecular Psychiatry, will also be presented this week at the annual meeting of the Society of Biological Psychiatry in San Francisco.
CB1 receptors are part of the endocannabinoid system, a diffuse network of chemicals and signaling pathways in the body that plays a role in memory formation, appetite, pain tolerance and mood. Animal studies have shown that psychoactive chemicals such as cannabis, along with certain neurotransmitters produced naturally in the body, can impair memory and reduce anxiety when they activate CB1 receptors in the brain. Lead author Alexander Neumeister, MD, director of the molecular imaging program in the Departments of Psychiatry and Radiology at NYU School of Medicine, and colleagues are the first to demonstrate through brain imaging that people with PTSD have markedly lower concentrations of at least one of these neurotransmitters -- an endocannabinoid known as anandamide -- than people without PTSD. Their study, which was supported by three grants from the National Institutes of Health, illuminates an important biological fingerprint of PTSD that could help improve the accuracy of PTSD diagnoses, and points the way to medications designed specifically to treat trauma.
"There's not a single pharmacological treatment out there that has been developed specifically for PTSD," says Dr. Neumeister. "That's a problem. There's a consensus among clinicians that existing pharmaceutical treatments such as antidepressant simple do not work. In fact, we know very well that people with PTSD who use marijuana -- a potent cannabinoid -- often experience more relief from their symptoms than they do from antidepressants and other psychiatric medications. Clearly, there's a very urgent need to develop novel evidence-based treatments for PTSD."
The study divided 60 participants into three groups: participants with PTSD; participants with a history of trauma but no PTSD; and participants with no history of trauma or PTSD. Participants in all three groups received a harmless radioactive tracer that illuminates CB1 receptors when exposed to positron emissions tomography (PET scans). Results showed that participants with PTSD, especially women, had more CB1 receptors in brain regions associated with fear and anxiety than volunteers without PTSD. The PTSD group also had lower levels of the neurotransmitter anandamide, an endocannabinoid that binds to CB1. If anandamide levels are too low, Dr. Neumeister explains, the brain compensates by increasing the number of CB1 receptors. "This helps the brain utilize the remaining endocannabinoids," he says.
Much is still unknown about the effects of anandamide in humans but in rats the chemical has been shown to impair memory. "What is PTSD? It's an illness where people cannot forget what they have experienced," Dr. Neumeister says. "Our findings offer a possible biological explanation for this phenomenon."
Current diagnostics for PTSD rely on subjective measures and patient recall, making it difficult to accurately diagnose the condition or discern its symptoms from those of depression and anxiety. Biological markers of PTSD, such as tests for CB1 receptors and anandamide levels, could dramatically improve diagnosis and treatment for trauma victims.
Among the 1.7 million men and women who have served in the wars in Iraq and Afghanistan, an estimated 20% have PTSD. But PTSD is not limited to soldiers. Trauma from sexual abuse, domestic violence, car accidents, natural disaster, violent assault or even a life-threatening medical diagnosis can lead to PTSD. The condition affects nearly 8 million Americans annually.
These findings were made possible through the collaborative efforts of researchers at NYU School of Medicine, Yale School of Medicine, Harvard Medical School, the Department of Veterans Affairs National Center for PTSD and the University of California at Irvine.
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